Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 17/20 | 0.42 |
| ▸ | PDE4A | P27815 | 16/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2889671 | 0.87 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL2887299 | 0.87 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL2889672 | 0.87 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL2890083 | 0.85 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL5733765 | 0.80 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL5972842 | 0.78 | PTPRC (0.49) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL5972846 | 0.78 | PTPRC (0.49) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL2887615 | 0.78 | PDE4A (0.50) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL2887619 | 0.78 | PDE4A (0.50) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL2887622 | 0.78 | PDE4A (0.50) | PDE4DPDE4APDE4BPDE4CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1650193-A2 | 6-Phenylphenanthridines with PDE-IV inhibiting activity | ALTANA Pharma AG (DE) | 2006-04-26 | — | — | EP | disclosed |
| EP-1147089-B1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-12-07 | — | — | EP | disclosed |
| US-6476025-B1 | Phenylphennanthridines with PDE-IV inhibiting activity | ALTANA PHARMA AG (DE) | 2002-11-05 | — | — | US | disclosed |
| EP-1147089-A1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000042020-A1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |