SCHEMBL5734571

SCHEMBL5734571

Nc1cc(-c2ccc(C(=O)N3CCN(S(=O)(=O)c4ccc5cc(Cl)ccc5c4)CC3)cc2)no1

nearest known ligand 0.54

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
F10 P00742 19/20 0.54
ATM Q13315 1/20 0.52
F2 P00734 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5736217 0.84 F10 (0.54) F10ATMF2
Hydrochloric Acid SCHEMBL6197875 0.83 F10 (0.60) F10ATM
SCHEMBL5736203 0.83 ATM (0.54) F10ATMF2
Hydrochloric Acid SCHEMBL6200589 0.83 F10 (0.54) F10ATMF2
Hydrochloric Acid SCHEMBL6200546 0.83 F10 (0.54) F10ATMF2
SCHEMBL5736178 0.83 F10 (0.64) F10ATM
Hydrochloric Acid SCHEMBL6194130 0.83 F10 (0.55) F10ATMF2
SCHEMBL5736371 0.82 F10 (0.57) F10ATMF2
SCHEMBL7070562 0.82 F10 (0.57) F10ATMF2
SCHEMBL5736610 0.82 F10 (0.56) F10ATMF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0986551-B1 SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA PHARMACEUTICAL (JP) 2006-08-02 EP disclosed
US-6359134-B1 ANTICOAGULANTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-03-19 US disclosed
EP-0986551-A1 SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Pharmaceutical Company Limited (JP) 2000-03-22 EP disclosed
WO-1998054164-A1 SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-12-03 WO disclosed