Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.41 |
| ▸ | PDE4A | P27815 | 7/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5735597 | 1.00 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CPARP15 | |
| SCHEMBL2889028 | 1.00 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CPARP15 | |
| SCHEMBL2888128 | 0.90 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CPARP15 | |
| SCHEMBL2888130 | 0.90 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CPARP15 | |
| SCHEMBL2888129 | 0.90 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CPARP15 | |
| SCHEMBL2882478 | 0.86 | MAOB (0.42) | PDE4DPDE4APDE4BPDE4CIGF1R | |
| SCHEMBL2882481 | 0.86 | MAOB (0.42) | PDE4DPDE4APDE4BPDE4CIGF1R | |
| SCHEMBL2882477 | 0.86 | MAOB (0.42) | PDE4DPDE4APDE4BPDE4CIGF1R | |
| SCHEMBL2887239 | 0.86 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CPDE3A | |
| SCHEMBL2887238 | 0.86 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1650193-A2 | 6-Phenylphenanthridines with PDE-IV inhibiting activity | ALTANA Pharma AG (DE) | 2006-04-26 | — | — | EP | disclosed |
| EP-1147089-B1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-12-07 | — | — | EP | disclosed |
| US-6476025-B1 | Phenylphennanthridines with PDE-IV inhibiting activity | ALTANA PHARMA AG (DE) | 2002-11-05 | — | — | US | disclosed |