Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.68 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.68 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL938163 | 0.86 | MAPK14 (0.70) | MAPK14MAPK11ERBB2MAPK13MAPK12 | |
| SCHEMBL5732952 | 0.85 | MAPK14 (0.78) | MAPK14MAPK11ERBB2MAPK13MAPK12 | |
| SCHEMBL938855 | 0.83 | MAPK14 (0.75) | MAPK14MAPK11ERBB2MAPK13MAPK12 | |
| SCHEMBL4594410 | 0.82 | MAPK14 (0.82) | MAPK14MAPK11ERBB2MAPK13MAPK12 | |
| SCHEMBL524524 | 0.82 | MAPK14 (1.00) | MAPK14MAPK11ERBB2MAPK13MAPK12 | |
| SCHEMBL937570 | 0.81 | MAPK14 (0.71) | MAPK14MAPK11ERBB2MAPK13MAPK12 | |
| SCHEMBL937420 | 0.79 | MAPK14 (0.68) | MAPK14MAPK11ERBB2MAPK13MAPK12 | |
| SCHEMBL937277 | 0.79 | MAPK14 (0.74) | MAPK14MAPK11ERBB2MAPK13MAPK12 | |
| SCHEMBL937765 | 0.79 | MAPK14 (0.67) | MAPK14MAPK11ERBB2MAPK13MAPK12 | |
| SCHEMBL937745 | 0.78 | MAPK14 (0.66) | MAPK14MAPK11ERBB2MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056725-B1 | INHIBITION OF RAF KINASE USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS | BAYER PHARMACEUTICALS CORP (US) | 2006-06-07 | — | — | EP | claimed |