Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.51 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | TRHR | P34981 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5734860 | 0.84 | DPP4 (0.52) | DPP4DPP8DPP9OPRD1OPRM1 | |
| SCHEMBL5737135 | 0.84 | DPP4 (0.49) | DPP4DPP8DPP9OPRD1OPRM1 | |
| SCHEMBL5734227 | 0.83 | DPP4 (0.53) | DPP4DPP8DPP9OPRD1OPRM1 | |
| SCHEMBL5733388 | 0.83 | DPP4 (0.52) | DPP4DPP8DPP9OPRD1TRHR | |
| SCHEMBL5733506 | 0.82 | DPP4 (0.50) | DPP4DPP8DPP9OPRD1OPRM1 | |
| SCHEMBL5737016 | 0.80 | DPP4 (0.47) | DPP4DPP8DPP9OPRD1OPRM1 | |
| Rovatirelin SCHEMBL14280927 | 0.80 | DPP4 (0.42) | DPP4DPP8DPP9TRHR | |
| Rovatirelin SCHEMBL20811796 | 0.80 | DPP4 (0.42) | DPP4DPP8DPP9TRHR | |
| Rovatirelin SCHEMBL27063662 | 0.80 | DPP4 (0.42) | DPP4DPP8DPP9TRHR | |
| Rovatirelin SCHEMBL14306794 | 0.80 | DPP4 (0.42) | DPP4DPP8DPP9TRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933379-B1 | NOVEL PEPTIDE DERIVATIVES HAVING THIAZOLYL-ALANINE RESIDUE | SHIONOGI & CO (JP) | 2006-03-22 | — | — | EP | disclosed |
| US-6319902-B1 | TO ACTIVATE THE CENTRAL NERVOUS SYSTEM, SUCH AS, FOR EXAMPLE, SUSTAINED ACETYLCHOLINE RELEASING ACTION, ANTI-RESERPINE ACTION AND LOCOMOTOR INCREMENT | SHIONOGI & CO., LTD. (JP) | 2001-11-20 | — | — | US | disclosed |
| EP-0933379-A1 | NOVEL PEPTIDE DERIVATIVES HAVING THIAZOLYL-ALANINE RESIDUE | SHIONOGI & CO., LTD. (JP) | 1999-08-04 | — | — | EP | disclosed |