Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | NMT1 | P30419 | 2/20 | 0.42 |
| ▸ | NMT2 | O60551 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5736793 | 1.00 | NR1H4 (0.58) | NR1H4ALDH1A1P4HTMLMNAL3MBTL1 | |
| SCHEMBL13427742 | 0.89 | NR1H4 (0.59) | NR1H4ALDH1A1P4HTMLMNAL3MBTL1 | |
| SCHEMBL1563369 | 0.89 | NR1H4 (0.59) | NR1H4ALDH1A1P4HTMLMNAL3MBTL1 | |
| SCHEMBL2804643 | 0.83 | NR1H4 (0.79) | NR1H4ALDH1A1LMNAL3MBTL1MEN1 | |
| SCHEMBL2804642 | 0.83 | NR1H4 (0.79) | NR1H4ALDH1A1LMNAL3MBTL1MEN1 | |
| SCHEMBL2807676 | 0.83 | NR1H4 (0.79) | NR1H4ALDH1A1LMNAL3MBTL1MEN1 | |
| SCHEMBL13754900 | 0.79 | NR1H4 (0.47) | NR1H4ALDH1A1P4HTMMEN1KMT2A | |
| SCHEMBL1563358 | 0.79 | MAOB (0.51) | NR1H4ALDH1A1MAOBALOX5 | |
| SCHEMBL13754898 | 0.79 | MAOB (0.51) | NR1H4ALDH1A1MAOBALOX5 | |
| SCHEMBL1562632 | 0.79 | NR1H4 (0.47) | NR1H4ALDH1A1P4HTMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615899-A1 | ALPHA-SUBSTITUTED CARBOXYLIC ACIDS AS PPAR MODULATORS | PFIZER INC. (US) | 2006-01-18 | — | — | EP | disclosed |
| US-20050234066-A1 | Alpha substituted carboxylic acids | AGOURON PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
| US-20050187266-A1 | Alpha substituted carboxylic acids | PFIZER INC | 2005-08-25 | — | — | US | disclosed |
| WO-2004092145-A1 | ALPHA SUBSTITUTED CARBOXYLIC ACID AS PPAR MODULATORS | PFIZER INC. (US) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234066-A1 | Alpha substituted carboxylic acids | PPARG, PPARA, PPARD | NR1H4 70/4885ALDH1A1 177/4885P4HTM 3473/4885 |
| US-20050187266-A1 | Alpha substituted carboxylic acids | PPARG, PPARA, PPARD | NR1H4 70/4885ALDH1A1 177/4885P4HTM 3473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.