Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 20/20 | 0.69 |
| ▸ | CDK4 | P11802 | 19/20 | 0.69 |
| ▸ | CCND1 | P24385 | 19/20 | 0.69 |
| ▸ | CDK2 | P24941 | 19/20 | 0.69 |
| ▸ | CASK | O14936 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | CDK14 | O94921 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | MAK | P20794 | 1/20 | 0.53 |
| ▸ | CDK11B | P21127 | 1/20 | 0.53 |
| ▸ | TTK | P33981 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | CLK3 | P49761 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737837 | 0.92 | CDK1 (0.68) | CDK1CDK4CCND1CDK2CASK | |
| SCHEMBL4350455 | 0.89 | CDK1 (0.78) | CDK1CDK4CCND1CDK2CASK | |
| SCHEMBL4353083 | 0.89 | CDK1 (0.81) | CDK1CDK4CCND1CDK2CASK | |
| SCHEMBL4354110 | 0.89 | CDK1 (0.77) | CDK1CDK4CCND1CDK2CASK | |
| SCHEMBL5738103 | 0.89 | CDK1 (0.70) | CDK1CDK4CCND1CDK2CASK | |
| SCHEMBL4346567 | 0.88 | CDK1 (0.78) | CDK1CDK4CCND1CDK2CASK | |
| SCHEMBL4363546 | 0.88 | CDK1 (0.86) | CDK1CDK4CCND1CDK2CASK | |
| SCHEMBL4347535 | 0.87 | CDK1 (0.77) | CDK1CDK4CCND1CDK2CASK | |
| SCHEMBL4359305 | 0.87 | CDK1 (0.70) | CDK1CDK4CCND1CDK2CASK | |
| SCHEMBL4357275 | 0.85 | CDK1 (0.72) | CDK1CDK4CCND1CDK2CASK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628619-A2 | 4-AMINOPYRIMIDINE-5-ONE | F.HOFFMANN-LA ROCHE AG (CH) | 2006-03-01 | — | — | EP | claimed |
| WO-2004069139-A2 | 4-AMINOPYRIMIDIN-5-YL-METHANONE DERIVATIVES FOR INHIBITION OF CDK4 ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 2004-08-19 | — | — | WO | claimed |
| EP-1549309-A4 | SOMATOSTATIN ANALOGUE COMPOUNDS | CHEMBRIDGE RES LAB INC (US) | 2006-05-17 | — | — | EP | disclosed |
| EP-1549309-A2 | SOMATOSTATIN ANALOGUE COMPOUNDS | ChemBridge Research Laboratories, Inc. (US) | 2005-07-06 | — | — | EP | disclosed |
| US-6872827-B2 | Somatostatin analogue compounds | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2005-03-29 | — | — | US | disclosed |
| US-20040019069-A1 | Somatostatin analogue compounds | CHEMBRIDGE CORPORATION | 2004-01-29 | — | — | US | disclosed |
| WO-2003090677-A2 | SOMATOSTATIN ANALOGUE COMPOUNDS | CHEMBRIDGE RESEARCH LAB., LLC (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019069-A1 | Somatostatin analogue compounds | SSTR2, SSTR1, SSTR4 | CDK1 3170/4885CDK4 1187/4885CCND1 2635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.