Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | PAK4 | O96013 | 10/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582163 | 0.94 | RET (0.58) | RETPAK4KDRABCG2EGFR | |
| SCHEMBL3585951 | 0.92 | RET (0.58) | RETPAK4KDRABCG2EGFR | |
| SCHEMBL3581389 | 0.89 | RET (0.61) | RETPAK4KDRABCG2EGFR | |
| SCHEMBL3582018 | 0.88 | RET (0.62) | RETPAK4KDRABCG2EGFR | |
| SCHEMBL3584860 | 0.88 | RET (0.59) | RETPAK4KDRABCG2EGFR | |
| SCHEMBL3578669 | 0.87 | RET (0.61) | RETPAK4KDRABCG2EGFR | |
| SCHEMBL3591149 | 0.87 | RET (0.58) | RETPAK4KDRABCG2EGFR | |
| SCHEMBL3578638 | 0.86 | RET (0.64) | RETPAK4KDRABCG2EGFR | |
| SCHEMBL13154698 | 0.86 | RET (0.66) | RETPAK4KDRABCG2EGFR | |
| SCHEMBL3584700 | 0.85 | RET (0.61) | RETPAK4KDRABCG2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370553-B1 | RHO-KINASE INHIBITORS | BAYER AG (US) | 2006-05-10 | — | — | EP | claimed |
| EP-1370553-B1 | RHO-KINASE INHIBITORS | BAYER AG (US) | 2006-05-10 | — | — | EP | disclosed |