Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 19/20 | 0.71 |
| ▸ | KDR | P35968 | 10/20 | 0.67 |
| ▸ | EGFR | P00533 | 2/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.66 |
| ▸ | YES1 | P07947 | 2/20 | 0.66 |
| ▸ | CSK | P41240 | 2/20 | 0.66 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.66 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.66 |
| ▸ | GAK | O14976 | 1/20 | 0.66 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.66 |
| ▸ | STK10 | O94804 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | FYN | P06241 | 1/20 | 0.66 |
| ▸ | LYN | P07948 | 1/20 | 0.66 |
| ▸ | RET | P07949 | 1/20 | 0.66 |
| ▸ | HCK | P08631 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | FGR | P09769 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274750 | 0.91 | SRC (0.82) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3196245 | 0.87 | SRC (0.82) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3193688 | 0.86 | SRC (0.81) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3280393 | 0.85 | SRC (0.82) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3282949 | 0.84 | SRC (0.69) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3283111 | 0.84 | SRC (0.88) | SRCKDREGFRLCKYES1 | |
| SCHEMBL5951031 | 0.83 | SRC (0.76) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3277003 | 0.83 | SRC (1.00) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3275753 | 0.82 | SRC (0.69) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3276447 | 0.82 | SRC (0.69) | SRCKDREGFRLCKYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450808-B8 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF T CELL MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2006-01-04 | — | — | EP | disclosed |
| EP-1450808-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF T CELL MEDIATED DISEASES | Astrazeneca AB (SE) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003045395-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF T CELL MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2003-06-05 | — | — | WO | disclosed |