Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.67 |
| ▸ | EGFR | P00533 | 5/20 | 0.67 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052014 | 0.84 | KDR (0.77) | KDREGFRFLT1FLT4 | |
| SCHEMBL4045525 | 0.81 | KDR (1.00) | KDREGFRFLT1FLT4 | |
| SCHEMBL4048542 | 0.78 | KDR (0.80) | KDREGFRFLT1FLT4 | |
| SCHEMBL5516114 | 0.75 | KDR (0.80) | KDREGFRFLT1FLT4 | |
| SCHEMBL4044227 | 0.74 | KDR (0.79) | KDREGFRFLT1FLT4 | |
| SCHEMBL4051578 | 0.73 | KDR (1.00) | KDREGFR | |
| SCHEMBL5741783 | 0.73 | KDR (0.71) | KDREGFRFLT1FLT4 | |
| SCHEMBL4044449 | 0.73 | KDR (1.00) | KDREGFRFLT1FLT4 | |
| SCHEMBL1461250 | 0.73 | KDR (0.76) | KDREGFRFLT1FLT4 | |
| SCHEMBL5739951 | 0.72 | KDR (0.71) | KDREGFRFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |
| US-7244733-B2 | Pyrrolotriazine inhibitors of kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244733-B2 | Pyrrolotriazine inhibitors of kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-17 | — | — | US | disclosed |
| US-7112675-B2 | Pyrrolotriazine inhibitors of kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-09-26 | — | — | US | disclosed |