Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 18/20 | 0.53 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5461683 | 0.93 | POLB (0.44) | DPP4DPP8DPP9MEN1MAPK1 | |
| SCHEMBL5445504 | 0.92 | DPP4 (0.64) | DPP4DPP8DPP9 | |
| SCHEMBL5456858 | 0.91 | DPP4 (0.55) | DPP4DPP8DPP9 | |
| SCHEMBL5443078 | 0.91 | DPP4 (0.54) | DPP4DPP8DPP9 | |
| SCHEMBL5443593 | 0.90 | DPP4 (0.54) | DPP4DPP8DPP9 | |
| SCHEMBL5445522 | 0.85 | DPP4 (0.53) | DPP4DPP8DPP9 | |
| SCHEMBL5445312 | 0.85 | DPP4 (0.46) | DPP4DPP8DPP9GAA | |
| SCHEMBL5240832 | 0.85 | DPP4 (0.59) | DPP4DPP8DPP9 | |
| SCHEMBL5447585 | 0.83 | GCGR (0.46) | DPP4DPP8DPP9 | |
| SCHEMBL5452801 | 0.83 | DPP4 (0.45) | DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678138-A1 | PYRIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | Takeda Pharmaceutical Company Limited (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042488-A1 | PYRIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-05-12 | — | — | WO | disclosed |