Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4548897 | 0.85 | KDR (0.84) | KDRFGFR1CSF1RFGFR2FGFR3 | |
| SCHEMBL4548900 | 0.84 | KDR (0.76) | KDRFGFR1FGFR2FGFR3 | |
| SCHEMBL4548908 | 0.83 | KDR (0.71) | KDRFGFR1FGFR2FGFR3 | |
| SCHEMBL2748198 | 0.83 | KDR (0.84) | KDRFGFR1CSF1RFGFR2 | |
| SCHEMBL4548898 | 0.82 | KDR (1.00) | KDRFGFR1CSF1RFGFR2FGFR3 | |
| SCHEMBL4548899 | 0.81 | KDR (0.75) | KDRFGFR1 | |
| SCHEMBL4548910 | 0.81 | KDR (0.84) | KDRFGFR1CSF1RFGFR2FGFR3 | |
| SCHEMBL22540525 | 0.81 | KDR (0.74) | KDRFGFR1CSF1RFGFR2FGFR3 | |
| SCHEMBL2747256 | 0.81 | KDR (0.74) | KDRFGFR1CSF1RFGFR2FGFR3 | |
| SCHEMBL4548901 | 0.81 | KDR (0.79) | KDRFGFR1CSF1RFGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |