Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.71 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.44 |
| ▸ | KIF5B | P33176 | 1/20 | 0.44 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739937 | 0.88 | KDR (0.56) | KDREGFRERBB2MAPK14 | |
| SCHEMBL5739216 | 0.87 | KDR (0.55) | KDREGFRERBB2MAP2K1MAPK14 | |
| SCHEMBL5739989 | 0.87 | KDR (0.53) | KDREGFRRETKIF5BMAP2K1 | |
| SCHEMBL5740244 | 0.86 | KDR (0.54) | KDREGFRERBB2RETMAP2K1 | |
| SCHEMBL5739549 | 0.86 | KDR (0.54) | KDREGFRERBB2MAPK14 | |
| SCHEMBL5740324 | 0.86 | KDR (0.54) | KDREGFRERBB2MAP2K1MAPK14 | |
| SCHEMBL5739951 | 0.86 | KDR (0.71) | KDREGFRFLT1 | |
| SCHEMBL5739127 | 0.85 | KDR (0.56) | KDRMAPK14 | |
| SCHEMBL5740240 | 0.85 | KDR (0.53) | KDREGFRERBB2MAPK14 | |
| SCHEMBL5740103 | 0.85 | KDR (0.59) | KDREGFRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |