Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | FRK | P42685 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4548734 | 0.82 | KDR (0.52) | KDRRETPLK4AURKAMAPK13 | |
| SCHEMBL4548733 | 0.81 | KDR (0.57) | KDRRETPLK4AURKAMAPK13 | |
| SCHEMBL4548735 | 0.80 | KDR (0.52) | KDRRETPLK4AURKAMAPK13 | |
| SCHEMBL2747491 | 0.78 | KDR (0.78) | KDRRETPLK4AURKAMAPK13 | |
| SCHEMBL2437469 | 0.78 | KDR (0.71) | KDRRETPLK4AURKAMAPK13 | |
| SCHEMBL4548732 | 0.75 | KDR (0.55) | KDRRETPLK4AURKAMAPK13 | |
| SCHEMBL2748670 | 0.74 | KDR (0.62) | KDRRETPLK4AURKAMAPK13 | |
| SCHEMBL2747764 | 0.74 | KDR (0.67) | KDRAURKAABL1LCKLYN | |
| SCHEMBL4548685 | 0.74 | KDR (0.76) | KDRRETPLK4AURKAMAPK13 | |
| SCHEMBL4548771 | 0.73 | KDR (0.72) | KDRAURKALCKAURKBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |