Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 13/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.45 |
| ▸ | MET | P08581 | 5/20 | 0.45 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | KIT | P10721 | 3/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2898454 | 0.93 | AXL (0.51) | AXLCSF1RPDGFRAPDGFRBMET | |
| SCHEMBL2919897 | 0.87 | AXL (0.60) | AXLCSF1RPDGFRAPDGFRBMET | |
| SCHEMBL574161 | 0.82 | KDR (0.49) | AXLCSF1RPDGFRAPDGFRBMET | |
| SCHEMBL574737 | 0.82 | KDR (0.60) | AXLCSF1RPDGFRAPDGFRBMET | |
| SCHEMBL827559 | 0.82 | MAPK14 (0.47) | AXLCSF1RPDGFRAPDGFRBMET | |
| SCHEMBL827920 | 0.82 | MAPK14 (0.65) | AXLCSF1RPDGFRAMETKDR | |
| SCHEMBL574452 | 0.81 | KDR (0.54) | AXLCSF1RPDGFRAPDGFRBMET | |
| SCHEMBL574521 | 0.81 | AXL (0.46) | AXLCSF1RPDGFRAPDGFRBMET | |
| SCHEMBL574062 | 0.81 | MAPK14 (0.63) | AXLKDR | |
| SCHEMBL3665924 | 0.79 | AXL (0.61) | AXLCSF1RPDGFRAPDGFRBMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019015-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2012-02-09 | — | — | WO | disclosed |