Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739216 | 0.85 | KDR (0.55) | MAPK14 | |
| SCHEMBL1462082 | 0.84 | MAPK14 (0.72) | MAPK14MAPK11 | |
| SCHEMBL5738412 | 0.82 | MAPK14 (0.51) | MAPK14 | |
| SCHEMBL5740103 | 0.81 | KDR (0.59) | MAPK14 | |
| SCHEMBL5739719 | 0.79 | KDR (0.57) | MAPK14 | |
| SCHEMBL5739951 | 0.79 | KDR (0.71) | — | |
| SCHEMBL5740421 | 0.79 | KDR (0.52) | MAPK14 | |
| SCHEMBL5740927 | 0.78 | KDR (0.56) | MAPK14MAPK11 | |
| SCHEMBL5740097 | 0.78 | KDR (0.56) | MAPK14 | |
| SCHEMBL5738800 | 0.78 | KDR (0.48) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |