Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 6/20 | 0.45 |
| ▸ | FLT1 | P17948 | 3/20 | 0.44 |
| ▸ | FLT4 | P35916 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | TEK | Q02763 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4548913 | 0.86 | KDR (0.83) | KDRMAPK14BRAFTNNI3KMET | |
| SCHEMBL4548918 | 0.85 | KDR (0.72) | KDRMAPK14BRAFTNNI3KMET | |
| SCHEMBL4548921 | 0.85 | KDR (0.79) | KDRMAPK14BRAFTNNI3KMET | |
| SCHEMBL4548939 | 0.84 | KDR (0.77) | KDRMAPK14BRAFTNNI3KMET | |
| SCHEMBL4548914 | 0.84 | KDR (0.83) | KDRMAPK14BRAFTNNI3KMET | |
| SCHEMBL4548930 | 0.83 | KDR (0.69) | KDRMAPK14BRAFTNNI3KMET | |
| SCHEMBL4548912 | 0.83 | KDR (0.84) | KDRMAPK14BRAFTNNI3KFLT1 | |
| SCHEMBL4548917 | 0.82 | KDR (0.75) | KDRMAPK14BRAFTNNI3KMET | |
| SCHEMBL4812261 | 0.82 | KDR (1.00) | KDRMAPK14BRAFTNNI3KMET | |
| SCHEMBL4548925 | 0.82 | KDR (0.82) | KDRMAPK14BRAFTNNI3KMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |