Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.82 |
| ▸ | FLT1 | P17948 | 5/20 | 0.82 |
| ▸ | FLT4 | P35916 | 5/20 | 0.82 |
| ▸ | RET | P07949 | 2/20 | 0.82 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.82 |
| ▸ | KIT | P10721 | 2/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2747717 | 1.00 | KDR (0.82) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2467946 | 0.90 | KDR (0.78) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2433509 | 0.90 | KDR (1.00) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL29525857 | 0.90 | KDR (1.00) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2747450 | 0.88 | KDR (0.78) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2435793 | 0.88 | KDR (0.79) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2747675 | 0.87 | KDR (0.76) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL989240 | 0.87 | KDR (0.82) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2433194 | 0.87 | KDR (0.78) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2747005 | 0.86 | KDR (0.74) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |