Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739719 | 0.93 | KDR (0.57) | KDREGFRMAPK14 | |
| SCHEMBL5739861 | 0.92 | KDR (0.59) | KDREGFR | |
| SCHEMBL14451967 | 0.92 | KDR (0.53) | KDREGFRMAPK14CLK1ABCG2 | |
| SCHEMBL5740103 | 0.88 | KDR (0.59) | KDREGFRMAPK14 | |
| SCHEMBL5740473 | 0.87 | MAP2K1 (0.52) | KDREGFRMAPK14MAP2K1 | |
| SCHEMBL5739951 | 0.87 | KDR (0.71) | KDREGFR | |
| SCHEMBL5740556 | 0.86 | KDR (0.62) | KDREGFRMAPK14MAP2K1 | |
| SCHEMBL5740927 | 0.86 | KDR (0.56) | KDREGFRMAPK14 | |
| SCHEMBL5740097 | 0.86 | KDR (0.56) | KDREGFRMAPK14 | |
| SCHEMBL5741836 | 0.85 | KDR (0.72) | KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |