Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.58 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | BCR | P11274 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 4/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29590073 | 0.96 | SRC (0.62) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL1893090 | 0.96 | SRC (0.62) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL5740938 | 0.91 | SRC (0.58) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL6381695 | 0.88 | SRC (0.62) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL5459297 | 0.88 | SRC (0.62) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL24010298 | 0.87 | SRC (0.60) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL6688486 | 0.87 | SRC (0.58) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL5253842 | 0.86 | SRC (0.60) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL4741681 | 0.85 | SRC (0.66) | SRCABL1BCREGFRERBB2 | |
| SCHEMBL4296487 | 0.85 | SRC (0.54) | SRCABL1BCREGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |