Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 17/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4335380 | 0.86 | GRM5 (0.49) | GRM5HCRTR1HCRTR2 | |
| SCHEMBL28780313 | 0.76 | GRM5 (0.80) | GRM5HCRTR1HCRTR2 | |
| SCHEMBL4027232 | 0.71 | KMT2A (0.47) | — | |
| SCHEMBL8244818 | 0.69 | NR1H4 (0.67) | GRM5 | |
| SCHEMBL5333513 | 0.69 | GRM5 (0.94) | GRM5 | |
| SCHEMBL8242428 | 0.69 | GRM5 (0.98) | GRM5 | |
| SCHEMBL5310857 | 0.68 | GRM5 (0.94) | GRM5 | |
| SCHEMBL5306538 | 0.68 | GRM5 (1.00) | GRM5 | |
| SCHEMBL5327585 | 0.68 | GRM5 (0.75) | GRM5HCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL5331967 | 0.68 | NR1H4 (0.65) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716152-A2 | FUSED HETROCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC RECEPTOR ANTAGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080397-A2 | FUSED HETROCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC RECEPTOR ANTAGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |