Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 16/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743356 | 0.80 | IKBKB (0.56) | IKBKBCHUK | |
| Hydrochloric Acid SCHEMBL5429880 | 0.72 | IKBKB (0.50) | IKBKBCDK2CDK1CHEK1CCNA2 | |
| SCHEMBL5741793 | 0.71 | IKBKB (0.59) | IKBKBCHUK | |
| SCHEMBL5439238 | 0.70 | IKBKB (0.69) | IKBKBCDK2CDK1 | |
| Hydrochloric Acid SCHEMBL5428605 | 0.70 | IKBKB (0.60) | IKBKBCDK2CDK1CHEK1CCNA2 | |
| SCHEMBL5744024 | 0.69 | IKBKB (0.59) | IKBKBCHUK | |
| Hydrochloric Acid SCHEMBL5433883 | 0.68 | IKBKB (0.67) | IKBKBCDK2CDK1 | |
| SCHEMBL14046517 | 0.67 | IKBKB (0.67) | IKBKB | |
| Hydrochloric Acid SCHEMBL5424030 | 0.66 | IKBKB (0.48) | IKBKBCDK2CDK1CHEK1CCNA2 | |
| SCHEMBL14046516 | 0.66 | IKBKB (0.80) | IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678146-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | claimed |
| WO-2005040133-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-05-06 | — | — | WO | claimed |