Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026394 | 1.00 | BCHE (0.53) | BCHEKDM4CKMT2AMEN1GRIN2D | |
| SCHEMBL4023796 | 0.92 | BCHE (0.53) | BCHEKDM4CKMT2AMEN1KDM4E | |
| SCHEMBL4028072 | 0.89 | BCHE (0.52) | BCHEKDM4CKMT2AGRIN2DGRIN3B | |
| SCHEMBL4025481 | 0.88 | BCHE (0.58) | BCHEKDM4CKMT2AMEN1GRIN2D | |
| SCHEMBL4027325 | 0.86 | BCHE (0.56) | BCHEKDM4CKMT2AMEN1GRIN2D | |
| SCHEMBL990798 | 0.85 | BCHE (0.57) | BCHEKDM4CKMT2AKDM4EMAPT | |
| SCHEMBL1680336 | 0.85 | BCHE (0.57) | BCHEKDM4CKMT2AKDM4EMAPT | |
| SCHEMBL3346743 | 0.85 | BCHE (0.57) | BCHEKDM4CKMT2AKDM4EMAPT | |
| SCHEMBL4027162 | 0.84 | BCHE (0.64) | BCHEKDM4CKMT2AMEN1KDM4E | |
| SCHEMBL4030199 | 0.84 | BCHE (0.56) | BCHEKDM4CKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611104-A1 | TETRAHYDROISOQUINOLYL ACETAMIDE DERIVATIVES FOR USE AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004085403-A1 | TETRAHYDROISOQUINOLYL ACETAMIDE DERIVATIVES FOR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-10-07 | — | — | WO | disclosed |