Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5411479 | 0.82 | HSD17B10 (0.57) | HSD17B10SMN1; SMN2NPC1POLBUCHL1 | |
| SCHEMBL5411482 | 0.82 | HSD17B10 (0.57) | HSD17B10SMN1; SMN2NPC1POLBUCHL1 | |
| SCHEMBL13819936 | 0.82 | HSD17B10 (0.57) | HSD17B10SMN1; SMN2NPC1POLBUCHL1 | |
| SCHEMBL13827672 | 0.81 | POLB (0.53) | HSD17B10SMN1; SMN2NPC1POLBUCHL1 | |
| SCHEMBL10724820 | 0.79 | HSD17B10 (0.53) | HSD17B10SMN1; SMN2NPC1POLBUCHL1 | |
| SCHEMBL15828464 | 0.79 | HSD17B10 (0.53) | HSD17B10SMN1; SMN2NPC1UCHL1LMNA | |
| SCHEMBL28133679 | 0.79 | HSD17B10 (0.62) | HSD17B10SMN1; SMN2NPC1UCHL1LMNA | |
| SCHEMBL23157177 | 0.78 | HSD17B10 (0.50) | HSD17B10SMN1; SMN2NPC1POLBLMNA | |
| SCHEMBL12158537 | 0.78 | HSD17B10 (0.52) | HSD17B10SMN1; SMN2NPC1POLBUCHL1 | |
| SCHEMBL15113629 | 0.78 | HSD17B10 (0.52) | HSD17B10SMN1; SMN2NPC1POLBUCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678146-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040133-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-05-06 | — | — | WO | disclosed |