Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | ACP1 | P24666 | 6/20 | 0.47 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 2/20 | 0.46 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742142 | 0.97 | MAPT (0.57) | RAB9AMAPTKMT2ATP53HPGD | |
| SCHEMBL5743347 | 0.95 | AGPAT2 (0.57) | RAB9AMAPTKMT2ATP53HPGD | |
| SCHEMBL5743457 | 0.95 | ACP1 (0.54) | RAB9AMAPTKMT2ATP53HPGD | |
| SCHEMBL5741286 | 0.93 | MAPT (0.53) | RAB9AMAPTKMT2ATP53HPGD | |
| SCHEMBL5741057 | 0.92 | ACP1 (0.57) | RAB9AMAPTKMT2ATP53HPGD | |
| SCHEMBL5740501 | 0.90 | AGPAT2 (0.52) | RAB9AMAPTKMT2ATP53HPGD | |
| SCHEMBL5743773 | 0.90 | AGPAT2 (0.52) | RAB9AMAPTKMT2ATP53HPGD | |
| SCHEMBL5743423 | 0.90 | MAPT (0.48) | RAB9AMAPTKMT2ATP53HPGD | |
| SCHEMBL5742562 | 0.90 | MAPT (0.53) | RAB9AMAPTKMT2ATP53HPGD | |
| SCHEMBL5740308 | 0.89 | AGPAT2 (0.48) | RAB9AMAPTKMT2ATP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |