SCHEMBL5743422

SCHEMBL5743422

CC(C)(C)OC(=O)Nc1cccc(C(F)(F)F)c1-c1cc(Oc2cccc3ccc(N)nc23)ncn1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 2/20 0.41
PLAU P00749 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1042007 0.85
SCHEMBL1041212 0.72 TRPV1 (0.63) TRPV1
SCHEMBL14354958 0.71
SCHEMBL1042009 0.70 KDR (0.39) TRPV1
SCHEMBL1042638 0.69 TRPV1 (0.48) TRPV1
SCHEMBL1041896 0.69 MCHR1 (0.50)
SCHEMBL1041888 0.69 TRPV1 (0.53) TRPV1
SCHEMBL1078409 0.69 MCHR1 (0.45) TRPV1
SCHEMBL14354959 0.68
SCHEMBL5142688 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1717220-A2 Vanilloid receptor ligands and their use in treatments Amgen, Inc (US) 2006-11-02 EP disclosed