Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2888181 | 1.00 | PDE4A (0.44) | PDE4APDE4DPDE4BPDE4CIGF1R | |
| SCHEMBL2888178 | 1.00 | PDE4A (0.44) | PDE4APDE4DPDE4BPDE4CIGF1R | |
| SCHEMBL2887250 | 0.93 | C5AR1 (0.41) | PDE4APDE4DPDE4BPDE4CIGF1R | |
| SCHEMBL2887254 | 0.93 | C5AR1 (0.41) | PDE4APDE4DPDE4BPDE4CIGF1R | |
| SCHEMBL2887247 | 0.93 | C5AR1 (0.41) | PDE4APDE4DPDE4BPDE4CIGF1R | |
| SCHEMBL2882481 | 0.87 | MAOB (0.42) | PDE4APDE4DPDE4BPDE4CIGF1R | |
| SCHEMBL2882477 | 0.87 | MAOB (0.42) | PDE4APDE4DPDE4BPDE4CIGF1R | |
| SCHEMBL2882478 | 0.87 | MAOB (0.42) | PDE4APDE4DPDE4BPDE4CIGF1R | |
| SCHEMBL2881661 | 0.85 | PDE4D (0.46) | PDE4APDE4DPDE4BPDE4CMEN1 | |
| SCHEMBL2888513 | 0.85 | PDE4D (0.46) | PDE4APDE4DPDE4BPDE4CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1650193-A2 | 6-Phenylphenanthridines with PDE-IV inhibiting activity | ALTANA Pharma AG (DE) | 2006-04-26 | — | — | EP | disclosed |
| EP-1147089-B1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2005023253-A1 | USE OF PDE4 INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS | ALTANA PHARMA AG (DE) | 2005-03-17 | — | — | WO | disclosed |
| US-6476025-B1 | Phenylphennanthridines with PDE-IV inhibiting activity | ALTANA PHARMA AG (DE) | 2002-11-05 | — | — | US | disclosed |