Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.68 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3526216 | 1.00 | EGFR (0.68) | EGFRSRCERBB2AURKAINSR | |
| SCHEMBL3524857 | 1.00 | EGFR (0.68) | EGFRSRCERBB2AURKAINSR | |
| SCHEMBL3521731 | 0.93 | EGFR (0.58) | EGFRSRCFBP1 | |
| SCHEMBL3523317 | 0.88 | EGFR (0.52) | EGFRSRC | |
| SCHEMBL5745419 | 0.86 | EGFR (0.62) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL3522698 | 0.86 | EGFR (0.62) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL3526179 | 0.86 | EGFR (0.62) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL3522474 | 0.86 | EGFR (0.62) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL5734606 | 0.86 | EGFR (0.62) | EGFRERBB2AURKAINSRFBP1 | |
| SCHEMBL3523730 | 0.86 | EGFR (0.62) | EGFRERBB2AURKAINSRFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622620-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER | AstraZeneca AB (SE) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096226-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2004-11-11 | — | — | WO | disclosed |