SCHEMBL5744076

SCHEMBL5744076

CN1CC[C@@H](Oc2cc(NS(=O)(=O)c3c(Cl)sc(Cl)c3Cl)ccc2C(F)(F)F)C1

nearest known ligand 0.63

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 19/20 0.63
FPR2 P25090 1/20 0.37
PROKR1 Q8TCW9 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5743566 0.93 UTS2R (0.65) UTS2R
SCHEMBL5744852 0.88 UTS2R (0.62) UTS2R
SCHEMBL5745120 0.88 UTS2R (0.62) UTS2R
SCHEMBL5835448 0.86 UTS2R (0.66) UTS2RFPR2PROKR1
SCHEMBL5835439 0.86 UTS2R (0.66) UTS2RFPR2PROKR1
SCHEMBL5744542 0.85 UTS2R (0.68) UTS2R
SCHEMBL6828353 0.85 UTS2R (0.63) UTS2R
SCHEMBL6828351 0.85 UTS2R (0.63) UTS2R
SCHEMBL5835445 0.85 UTS2R (0.65) UTS2RFPR2PROKR1
SCHEMBL5835410 0.85 UTS2R (0.69) UTS2RFPR2PROKR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1385840-B1 SULFONAMIDES SMITHKLINE BEECHAM CORP (US) 2006-10-04 EP claimed
US-7091204-B2 Sulfonamides SMITHKLINE BEECHAM CORPORATION (US) 2006-08-15 US disclosed