Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.69 |
| ▸ | EGFR | P00533 | 14/20 | 0.66 |
| ▸ | IGF1R | P08069 | 5/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL518359 | 0.91 | ALK (0.74) | ALKEGFRIGF1RKCNH2 | |
| SCHEMBL517766 | 0.88 | ALK (0.75) | ALKEGFRIGF1RKCNH2 | |
| SCHEMBL517604 | 0.87 | ALK (0.81) | ALKEGFRIGF1RKCNH2 | |
| SCHEMBL518394 | 0.82 | ALK (0.83) | ALKEGFRIGF1RKCNH2INSR | |
| SCHEMBL29355191 | 0.82 | ALK (1.00) | ALKEGFRIGF1RKCNH2 | |
| SCHEMBL517412 | 0.82 | ALK (1.00) | ALKEGFRIGF1RKCNH2 | |
| SCHEMBL518078 | 0.82 | EGFR (0.83) | ALKEGFRIGF1RINSR | |
| SCHEMBL517293 | 0.82 | ALK (0.84) | ALKEGFRIGF1RKCNH2 | |
| SCHEMBL518047 | 0.82 | ALK (0.84) | ALKEGFRIGF1RKCNH2 | |
| SCHEMBL10207758 | 0.82 | ALK (0.59) | ALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601186-A2 | 4-(1H-INDOL-3-YL)-PYRIMIDINES AS ALK INHIBITORS | AstraZeneca AB (SE) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017239-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |