Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tolterodine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 7/20 | 0.90 |
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.90 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.90 |
| ▸ | MAPT | P10636 | 3/20 | 0.90 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.90 |
| ▸ | HRH1 | P35367 | 2/20 | 0.90 |
| ▸ | LMNA | P02545 | 2/20 | 0.90 |
| ▸ | ESR1 | P03372 | 1/20 | 0.90 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.90 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.90 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.90 |
| ▸ | HRH2 | P25021 | 1/20 | 0.90 |
| ▸ | HTR2A | P28223 | 1/20 | 0.90 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.90 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.90 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.90 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.90 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.90 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolterodine SCHEMBL3064 | 0.95 | CHRM3 (1.00) | CHRM3CHRM2CHRM1MAPTCHRM5 | |
| Tolterodine SCHEMBL29635996 | 0.95 | CHRM3 (1.00) | CHRM3CHRM2CHRM1MAPTCHRM5 | |
| Tolterodine SCHEMBL29379290 | 0.95 | CHRM3 (1.00) | CHRM3CHRM2CHRM1MAPTCHRM5 | |
| Tolterodine SCHEMBL36882 | 0.95 | CHRM3 (1.00) | CHRM3CHRM2CHRM1MAPTCHRM5 | |
| Tolterodine SCHEMBL580446 | 0.95 | CHRM3 (1.00) | CHRM3CHRM2CHRM1MAPTCHRM5 | |
| Tolterodine SCHEMBL820421 | 0.95 | CHRM3 (1.00) | CHRM3CHRM2CHRM1MAPTCHRM5 | |
| Tolterodine SCHEMBL1989702 | 0.94 | CHRM3 (0.88) | CHRM3CHRM2CHRM1MAPTCHRM5 | |
| Tolterodine SCHEMBL1260827 | 0.94 | CHRM3 (0.97) | CHRM3CHRM2CHRM1MAPTCHRM5 | |
| Tolterodine SCHEMBL4840247 | 0.94 | CHRM3 (0.97) | CHRM3CHRM2CHRM1MAPTCHRM5 | |
| Tolterodine SCHEMBL617185 | 0.94 | CHRM3 (0.97) | CHRM3CHRM2CHRM1MAPTCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601944-B1 | TRANSDERMAL PATCH AND METHOD FOR AUGMENTING ADHESIVE STRENGTH THEREOF | HISAMITSU PHARMACEUTICAL CO (JP) | 2021-02-17 | — | — | EP | claimed |
| US-20130195957-A1 | PATCH AND METHOD FOR ENHANCING ADHESION FORCE OF THE SAME | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2013-08-01 | — | — | US | claimed |
| EP-2601944-A1 | TRANSDERMAL PATCH AND METHOD FOR AUGMENTING ADHESIVE STRENGTH THEREOF | Hisamitsu Pharmaceutical Co., Inc. (JP) | 2013-06-12 | — | — | EP | claimed |
| CN-117129595-B | Analysis method of tolote Luo Zhong related substances | 正大制药（青岛）有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-117129595-A | Analysis method of tolote Luo Zhong related substances | 正大制药（青岛）有限公司 | 2023-11-28 | — | — | CN | disclosed |
| CN-113717063-B | Preparation and purification method of tulobuterol | 北京泰德制药股份有限公司 | 2023-08-08 | — | — | CN | disclosed |
| EP-2601944-B1 | TRANSDERMAL PATCH AND METHOD FOR AUGMENTING ADHESIVE STRENGTH THEREOF | HISAMITSU PHARMACEUTICAL CO (JP) | 2021-02-17 | — | — | EP | disclosed |
| US-20130195957-A1 | PATCH AND METHOD FOR ENHANCING ADHESION FORCE OF THE SAME | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2013-08-01 | — | — | US | disclosed |
| US-20130195957-A1 | PATCH AND METHOD FOR ENHANCING ADHESION FORCE OF THE SAME | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2013-08-01 | — | — | US | disclosed |
| EP-2601944-A1 | TRANSDERMAL PATCH AND METHOD FOR AUGMENTING ADHESIVE STRENGTH THEREOF | Hisamitsu Pharmaceutical Co., Inc. (JP) | 2013-06-12 | — | — | EP | disclosed |
| EP-2601944-A1 | TRANSDERMAL PATCH AND METHOD FOR AUGMENTING ADHESIVE STRENGTH THEREOF | Hisamitsu Pharmaceutical Co., Inc. (JP) | 2013-06-12 | — | — | EP | disclosed |
| CN-103153294-A | Transdermal patch and method for augmenting adhesive strength thereof | HISAMITSU PHARMACEUTICAL CO | 2013-06-12 | — | — | CN | disclosed |
| WO-2012017892-A1 | TRANSDERMAL PATCH AND METHOD FOR AUGMENTING ADHESIVE STRENGTH THEREOF | 久光製薬株式会社 (JP) | 2012-02-09 | — | — | WO | disclosed |