Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 8/20 | 0.58 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | CPB1 | P15086 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746701 | 0.95 | NR1H2 (0.53) | NR1H2NR1H3CHRM5ABL1BCR | |
| SCHEMBL4690915 | 0.89 | NR1H2 (0.73) | NR1H2NR1H3MAPTSMN1; SMN2NAMPT | |
| SCHEMBL4688172 | 0.82 | NR1H2 (0.74) | NR1H2NR1H3MAPTSMN1; SMN2 | |
| SCHEMBL4689739 | 0.82 | NR1H2 (0.57) | NR1H2NR1H3CHRM5MAPTSMN1; SMN2 | |
| SCHEMBL4684834 | 0.80 | NR1H2 (0.55) | NR1H2NR1H3CHRM5MAPTNAMPT | |
| SCHEMBL4692995 | 0.78 | NR1H2 (0.60) | NR1H2NR1H3CHRM5ABL1BCR | |
| SCHEMBL4450601 | 0.76 | NR1H2 (1.00) | NR1H2NR1H3MAPTSMN1; SMN2 | |
| SCHEMBL4688066 | 0.75 | NR1H2 (0.80) | NR1H2NR1H3MAPTSMN1; SMN2 | |
| SCHEMBL5745530 | 0.74 | NR1H2 (0.78) | NR1H2NR1H3MAPTSMN1; SMN2 | |
| SCHEMBL4685235 | 0.73 | NR1H2 (0.63) | NR1H2NR1H3MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646626-A1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2006-04-19 | — | — | EP | claimed |
| WO-2005005417-A1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2005-01-20 | — | — | WO | claimed |