Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL553410 | 0.92 | KLKB1 (0.75) | KLKB1 | |
| SCHEMBL554357 | 0.90 | KLKB1 (1.00) | KLKB1 | |
| SCHEMBL27901383 | 0.80 | KLKB1 (0.76) | KLKB1 | |
| SCHEMBL27901423 | 0.80 | KLKB1 (0.65) | KLKB1 | |
| SCHEMBL574484 | 0.80 | KLKB1 (0.80) | KLKB1 | |
| SCHEMBL553252 | 0.79 | KLKB1 (0.63) | KLKB1 | |
| SCHEMBL554059 | 0.79 | KLKB1 (1.00) | KLKB1 | |
| SCHEMBL553147 | 0.77 | KLKB1 (0.79) | KLKB1 | |
| SCHEMBL553901 | 0.76 | KLKB1 (0.62) | KLKB1 | |
| SCHEMBL553814 | 0.76 | KLKB1 (0.82) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601189-A1 | N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES AS INHIBITORS OF PLASMA KALLIKREIN | Novartis AG (CH) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017020-A1 | N-((6-AMINO-PYRIDIN-3-YL)METHYL)-HETEROARYL-CARBOXAMIDES AS INHIBITORS OF PLASMA KALLIKREIN | NOVARTIS AG (CH) | 2012-02-09 | — | — | WO | disclosed |