SCHEMBL5746763

SCHEMBL5746763

CSc1nc(CCc2ccccc2)cc(-c2ccc(F)c3ccccc23)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1B P28222 1/20 0.42
HTR2B P41595 1/20 0.42
GPR65 Q8IYL9 1/20 0.42
BACE1 P56817 2/20 0.41
SRC P12931 3/20 0.39
PLA2G2A P14555 2/20 0.37
KCNH2 Q12809 1/20 0.37
LMNA P02545 3/20 0.37
TP53 P04637 2/20 0.37
MEN1 O00255 1/20 0.37
ALDH1A1 P00352 1/20 0.37
TSHR P16473 1/20 0.37
PTBP1 P26599 1/20 0.37
HTT P42858 1/20 0.37
KMT2A Q03164 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
CREBBP Q92793 1/20 0.37
ESR1 P03372 3/20 0.36
ACP1 P24666 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5751623 0.85 HTR1B (0.41) HTR1BHTR2BGPR65KCNH2LMNA
SCHEMBL5750214 0.83 HTR1B (0.39) HTR1BHTR2BGPR65LMNATP53
SCHEMBL5750219 0.80 HTR1B (0.46) HTR1BHTR2BGPR65SRCLMNA
SCHEMBL5748464 0.80 HTR1B (0.47) HTR1BHTR2BGPR65LMNATP53
Hydrochloric Acid SCHEMBL5748498 0.79 BCHE (0.42) HTR1BHTR2BGPR65BACE1PLA2G2A
SCHEMBL5751060 0.78 HTR1B (0.41) HTR1BHTR2BGPR65BACE1PLA2G2A
SCHEMBL5748111 0.76 HTR1B (0.67) HTR1BHTR2BGPR65LMNATP53
SCHEMBL5749670 0.76 HTR1B (0.44) HTR1BHTR2BGPR65LMNATP53
SCHEMBL27360764 0.74 BACE1 (0.44) BACE1SRCKCNH2ALDH1A1ESR1
Maleic Acid SCHEMBL5749546 0.72 HTR1B (0.49) HTR1BHTR2BGPR65BACE1PLA2G2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1615916-A1 ANTIMICROBIAL 3.1.0 BICYCLOHEXYLPHENYL-OXAZOLIDINONE DERIVATIVES AND ANALOGUES Pharmacia & Upjohn Company LLC (US) 2006-01-18 EP claimed
WO-2004089943-A1 ANTIMICROBIAL [3.1.0] BICYCLOHEXYLPHENYL-OXAZOLIDINONE DERIVATIVES AND ANALOGUES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-10-21 WO claimed
EP-0901474-B1 ARYL PYRIMIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2006-04-19 EP disclosed
EP-1321169-A1 Combination of a serotonin receptor antagonist with a histidine decarboxylase inhibitor as a medicament Biofrontera Pharmaceuticals AG (DE) 2003-06-25 EP disclosed
US-5958934-A 5-HT 2B ANTAGONIST SYNTEX (U.S.A.) INC. (US) 1999-09-28 US disclosed
US-5952331-A SELECTIVE 5HT2B ANTAGONISTS; SEROTONIN RECEPTOR ANTAGONIST; TREATING DISORDERS OF THE GASTROINTESTINAL TRACK, RESTENOSIS, ASTHMA AND OBSTRUCTIVE AIRWAY DISEASE, PROSTATIC HYPERPLASIA, GENERALIZED ANXIETY, PANIC DISORDER SYNTEX (USA) INC. (US) 1999-09-14 US disclosed
EP-0901474-A1 ARYL PYRIMIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-03-17 EP disclosed
US-5863924-A Aryl pyrimidine derivatives SYNTEX (U.S.A.) INC. (US) 1999-01-26 US disclosed
WO-1997044326-A1 ARYL PYRIMIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1997-11-27 WO disclosed