Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 9/20 | 0.61 |
| ▸ | NR1H3 | Q13133 | 9/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4687950 | 0.92 | NR1H2 (0.72) | NR1H2NR1H3MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4689452 | 0.88 | NR1H2 (0.72) | NR1H2NR1H3MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5748763 | 0.83 | NR1H2 (0.65) | NR1H2NR1H3MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4687894 | 0.82 | NR1H2 (0.76) | NR1H2NR1H3MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4689082 | 0.79 | NR1H2 (0.78) | NR1H2NR1H3MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4450601 | 0.77 | NR1H2 (1.00) | NR1H2NR1H3MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5790936 | 0.77 | NR1H2 (0.67) | NR1H2NR1H3MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4686588 | 0.76 | NR1H2 (0.85) | NR1H2NR1H3MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4820919 | 0.75 | NR1H2 (0.64) | NR1H2NR1H3MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4685907 | 0.74 | NR1H2 (1.00) | NR1H2NR1H3MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646626-A1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005005417-A1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2005-01-20 | — | — | WO | disclosed |