SCHEMBL5747604

SCHEMBL5747604

COCCc1nc2c(N)nc3ccccc3c2n1CCCCNC(C)=O

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.61
TLR8 Q9NR97 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1950333 0.93 TLR7 (0.62) TLR7TLR8
SCHEMBL22522221 0.93 TLR7 (0.61) TLR7TLR8
SCHEMBL20806194 0.93 TLR7 (0.61) TLR7TLR8
SCHEMBL3865268 0.91 TLR7 (0.66) TLR7TLR8
SCHEMBL1950699 0.90 TLR7 (0.65) TLR7TLR8
SCHEMBL13937522 0.90 TLR7 (0.57) TLR7TLR8
SCHEMBL13937519 0.90 TLR7 (0.59) TLR7TLR8
SCHEMBL14592884 0.90 TLR7 (0.59) TLR7TLR8
SCHEMBL14592857 0.90 TLR7 (0.62) TLR7TLR8
SCHEMBL5751355 0.90 TLR7 (0.59) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1187613-B9 AMIDE SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES CO (US) 2006-10-25 EP claimed
EP-1187613-B1 AMIDE SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES CO (US) 2006-08-09 EP claimed
US-6451810-B1 AID IN CYTOKINE BIOSYNTHESIS 3M INNOVATIVE PROPERTIES COMPANY 2002-09-17 US claimed
EP-1187613-A4 AMIDE SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES CO (US) 2002-07-24 EP claimed
EP-1187613-A1 AMIDE SUBSTITUTED IMIDAZOQUINOLINES 3M Innovative Properties Company (US) 2002-03-20 EP claimed
WO-2000076505-A1 AMIDE SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES COMPANY (US) 2000-12-21 WO claimed