Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.75 |
| ▸ | NOS2 | P35228 | 3/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748997 | 1.00 | KCNH2 (0.75) | KCNH2NOS2NOS1MCHR1BACE1 | |
| SCHEMBL5746107 | 1.00 | KCNH2 (0.75) | KCNH2NOS2NOS1MCHR1BACE1 | |
| SCHEMBL9877613 | 0.98 | KCNH2 (0.71) | KCNH2NOS2NOS1MCHR1BACE1 | |
| SCHEMBL1269597 | 0.92 | KCNH2 (0.62) | KCNH2NOS2NOS1MCHR1BACE1 | |
| SCHEMBL24973117 | 0.86 | KCNH2 (1.00) | KCNH2 | |
| SCHEMBL31246249 | 0.86 | KCNH2 (1.00) | KCNH2 | |
| SCHEMBL29058172 | 0.86 | KCNH2 (1.00) | KCNH2 | |
| SCHEMBL10790586 | 0.86 | KCNH2 (1.00) | KCNH2 | |
| SCHEMBL6463178 | 0.86 | KCNH2 (1.00) | KCNH2 | |
| SCHEMBL29869667 | 0.86 | KCNH2 (1.00) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060293503-A1 | Polyaminopyridines and method for producing same | SUMITOMO SEIKA CHEMICALS CO., LTD (JP) | 2006-12-28 | — | — | US | disclosed |
| EP-1669390-A1 | POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2006-06-14 | — | — | EP | disclosed |
| EP-1628619-A2 | 4-AMINOPYRIMIDINE-5-ONE | F.HOFFMANN-LA ROCHE AG (CH) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004069139-A2 | 4-AMINOPYRIMIDIN-5-YL-METHANONE DERIVATIVES FOR INHIBITION OF CDK4 ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 2004-08-19 | — | — | WO | disclosed |