SCHEMBL5748490

SCHEMBL5748490

N#Cc1cccc2[c]c3ccccc3cc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.44
CA2 P00918 4/20 0.44
HTT P42858 1/20 0.42
TSHR P16473 1/20 0.35
KDM4E B2RXH2 4/20 0.35
ALDH1A1 P00352 3/20 0.35
GAA P10253 2/20 0.35
CLK1 P49759 1/20 0.34
DYRK1A Q13627 1/20 0.34
MCL1 Q07820 1/20 0.34
SLC9A1 P19634 1/20 0.33
NCOA3 Q9Y6Q9 1/20 0.33
IMPDH2 P12268 1/20 0.33
IMPDH1 P20839 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
LMNA P02545 1/20 0.32
MAPT P10636 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5749158 0.79 CA1 (0.41) CA1CA2HTTTSHRKDM4E
SCHEMBL18322219 0.76 HTT (0.53) CA1CA2HTTTSHRKDM4E
SCHEMBL32172 0.75 CA1 (0.52) CA1CA2HTTTSHRKDM4E
SCHEMBL31050903 0.75 CA1 (0.52) CA1CA2HTTTSHRKDM4E
SCHEMBL31050902 0.75 CA1 (0.52) CA1CA2HTTTSHRKDM4E
SCHEMBL3525889 0.74 CA1 (0.43) CA1CA2HTTTSHRKDM4E
SCHEMBL30858824 0.73 CA1 (0.50) CA1CA2HTTTSHRKDM4E
SCHEMBL16875674 0.73 CA1 (0.50) CA1CA2HTTTSHRKDM4E
SCHEMBL28488846 0.73 CA1 (0.50) CA1CA2HTTTSHRKDM4E
SCHEMBL4805734 0.73 CA1 (0.42) CA1CA2TSHRKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060293503-A1 Polyaminopyridines and method for producing same SUMITOMO SEIKA CHEMICALS CO., LTD (JP) 2006-12-28 US disclosed
EP-1669390-A1 POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 2006-06-14 EP disclosed