Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 11/20 | 0.58 |
| ▸ | FLT1 | P17948 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4802520 | 1.00 | TEK (0.58) | TEKFLT1KDRCAMKK2KDM4E | |
| SCHEMBL4802665 | 0.87 | TEK (0.68) | TEKFLT1KDRCAMKK2KDM4E | |
| SCHEMBL4797878 | 0.87 | TEK (0.68) | TEKFLT1KDRCAMKK2KDM4E | |
| SCHEMBL4801369 | 0.82 | TEK (0.70) | TEKFLT1KDRKDM4EALDH1A1 | |
| SCHEMBL4797422 | 0.81 | TEK (0.57) | TEKFLT1KDRKDM4EALDH1A1 | |
| SCHEMBL4797429 | 0.81 | TEK (0.57) | TEKFLT1KDRKDM4EALDH1A1 | |
| SCHEMBL4801078 | 0.80 | TEK (0.71) | TEKFLT1KDRKDM4EALDH1A1 | |
| SCHEMBL4795867 | 0.80 | TEK (0.74) | TEKFLT1KDRKDM4EALDH1A1 | |
| SCHEMBL4804616 | 0.79 | TEK (0.69) | TEKFLT1KDRKDM4EALDH1A1 | |
| SCHEMBL4798686 | 0.79 | TEK (0.72) | TEKFLT1KDRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537112-B1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | claimed |