Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045967 | 0.87 | KDR (0.65) | KDREGFRERBB2MAPK14 | |
| SCHEMBL5740324 | 0.85 | KDR (0.54) | KDREGFRERBB2MAPK14 | |
| SCHEMBL5740240 | 0.85 | KDR (0.53) | KDREGFRERBB2MAPK14TNNI3K | |
| SCHEMBL5740244 | 0.80 | KDR (0.54) | KDREGFRERBB2MAPK14 | |
| SCHEMBL5739216 | 0.79 | KDR (0.55) | KDREGFRERBB2MAPK14 | |
| SCHEMBL5739937 | 0.78 | KDR (0.56) | KDREGFRERBB2MAPK14 | |
| SCHEMBL5739127 | 0.78 | KDR (0.56) | KDRMAPK14 | |
| SCHEMBL5741956 | 0.77 | KDR (0.67) | KDREGFRMAPK14 | |
| SCHEMBL5739549 | 0.77 | KDR (0.54) | KDREGFRERBB2MAPK14 | |
| SCHEMBL5740103 | 0.76 | KDR (0.59) | KDREGFRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |