Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL575000 | 0.91 | BRAF (0.34) | BRAFMAPK14HCRTR1HCRTR2 | |
| SCHEMBL15191642 | 0.82 | BRAF (0.36) | BRAFMAPK14 | |
| SCHEMBL574846 | 0.80 | BRAF (0.33) | BRAFMAPK14HCRTR1HCRTR2 | |
| SCHEMBL15191841 | 0.78 | BRAF (0.37) | BRAFMAPK14 | |
| SCHEMBL15192209 | 0.78 | PDE10A (0.36) | MAPK14 | |
| SCHEMBL574889 | 0.78 | MEN1 (0.35) | BRAFMAPK14 | |
| SCHEMBL15198328 | 0.78 | BRAF (0.32) | BRAF | |
| SCHEMBL574504 | 0.77 | EGFR (0.37) | BRAFMAPK14 | |
| SCHEMBL15191686 | 0.77 | ROS1 (0.33) | HCRTR1HCRTR2 | |
| SCHEMBL574887 | 0.75 | BRAF (0.49) | BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601185-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012016993-A1 | DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-09 | — | — | WO | disclosed |