Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 10/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 8/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5457141 | 0.92 | DPP4 (0.57) | DPP4DPP9DPP8 | |
| SCHEMBL5443496 | 0.89 | DPP4 (0.48) | DPP4DPP9DPP8SMN1; SMN2 | |
| SCHEMBL5750259 | 0.87 | DPP4 (0.38) | DPP4DPP9DPP8NISCH | |
| SCHEMBL5806839 | 0.85 | DPP4 (0.46) | DPP4DPP9DPP8 | |
| Hydrochloric Acid SCHEMBL5442737 | 0.74 | DPP4 (0.61) | DPP4DPP9DPP8 | |
| SCHEMBL5753502 | 0.74 | CYP2E1 (0.48) | DPP4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5739328 | 0.74 | DPP4 (0.59) | DPP4DPP9DPP8 | |
| SCHEMBL5445193 | 0.73 | DPP4 (0.48) | DPP4DPP9DPP8 | |
| Hydrochloric Acid SCHEMBL5450843 | 0.72 | DPP4 (0.58) | DPP4DPP9DPP8 | |
| Hydrochloric Acid SCHEMBL5452759 | 0.72 | DPP4 (0.58) | DPP4DPP9DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678138-A1 | PYRIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | Takeda Pharmaceutical Company Limited (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042488-A1 | PYRIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-05-12 | — | — | WO | disclosed |