Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 9/20 | 0.73 |
| ▸ | FLT1 | P17948 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4796516 | 0.86 | TEK (1.00) | TEKFLT1KDRPIK3CDPIK3CA | |
| SCHEMBL4800553 | 0.78 | TEK (0.83) | TEKFLT1KDRPIK3CDPIK3CA | |
| SCHEMBL4800769 | 0.78 | TEK (0.83) | TEKFLT1KDRPIK3CDPIK3CA | |
| SCHEMBL4802696 | 0.77 | TEK (0.53) | TEKFLT1KDRPIK3CDPIK3CA | |
| SCHEMBL4799979 | 0.76 | TEK (0.76) | TEKFLT1KDRPIK3CDPIK3CA | |
| SCHEMBL4796261 | 0.75 | TEK (0.75) | TEKFLT1KDRMAPK14 | |
| SCHEMBL4798753 | 0.75 | TEK (1.00) | TEKFLT1KDRPIK3CDPIK3CA | |
| SCHEMBL4800579 | 0.72 | TEK (1.00) | TEKFLT1KDRPIK3CDPIK3CA | |
| SCHEMBL4796437 | 0.71 | TEK (0.84) | TEKFLT1KDRPIK3CDPIK3CA | |
| SCHEMBL4803254 | 0.71 | TEK (0.77) | TEKFLT1KDRPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537112-B1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | claimed |