Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 20/20 | 0.51 |
| ▸ | CNR2 | P34972 | 16/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.51 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.51 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749298 | 0.91 | CNR1 (0.49) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL5751784 | 0.89 | CNR1 (0.52) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL5746106 | 0.88 | CNR1 (0.51) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL1628156 | 0.87 | CNR1 (0.55) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL1628623 | 0.85 | CNR1 (0.53) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL5749393 | 0.83 | CNR1 (0.53) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL1627672 | 0.83 | CNR1 (0.54) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL1628617 | 0.82 | CNR1 (0.63) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL1628836 | 0.82 | CNR1 (0.55) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL1628694 | 0.81 | CNR1 (0.52) | CNR1CNR2GABRA1GABRB1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558252-A4 | SUBSTITUTED FURO 2,3-B| PYRIDINE DERIVATIVES | MERCK & CO INC (US) | 2006-05-17 | — | — | EP | disclosed |
| EP-1558252-A2 | SUBSTITUTED FURO 2,3-B] PYRIDINE DERIVATIVES | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004012671-A2 | SUBSTITUTED FURO [2,3-B] PYRIDINE DERIVATIVES | MERCK & CO., INC. (US) | 2004-02-12 | — | — | WO | disclosed |