Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.69 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599445 | 0.82 | KCNH2 (1.00) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL877343 | 0.82 | KCNH2 (1.00) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL120402 | 0.82 | KCNH2 (1.00) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5751337 | 0.78 | KCNH2 (0.90) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5751334 | 0.78 | KCNH2 (0.90) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5753988 | 0.78 | KCNH2 (0.90) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL11068676 | 0.77 | KCNH2 (0.53) | KCNH2CCR1DRD2 | |
| SCHEMBL5753760 | 0.77 | KCNH2 (0.62) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5460383 | 0.75 | KCNH2 (0.54) | KCNH2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5468540 | 0.74 | KCNH2 (0.53) | KCNH2OPRL1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2175728-B1 | SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2014-09-10 | — | — | EP | claimed |
| EP-1499606-B1 | 3, 4-DIHYDROQUINOLIN-2(1H)-ONE COMPOUNDS AS NR2B RECEPTOR ANTAGONISTS | PFIZER (US) | 2006-05-03 | — | — | EP | claimed |