Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | RGS12 | O14924 | 1/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3775916 | 0.90 | GSK3B (0.58) | GSK3BGSK3AMEN1RGS12GMNN | |
| SCHEMBL3781580 | 0.89 | GSK3B (0.66) | GSK3BGSK3AMEN1RGS12GMNN | |
| SCHEMBL5757844 | 0.88 | GSK3B (0.67) | GSK3BGSK3AMEN1RGS12GMNN | |
| SCHEMBL5754334 | 0.86 | GSK3B (0.67) | GSK3BGSK3AMEN1RGS12GMNN | |
| SCHEMBL5754325 | 0.85 | GSK3B (0.69) | GSK3BGSK3AMEN1RGS12GMNN | |
| SCHEMBL3771143 | 0.85 | GSK3B (0.52) | GSK3BGSK3AMEN1RGS12GMNN | |
| SCHEMBL1128498 | 0.85 | GSK3B (0.52) | GSK3BGSK3AMEN1RGS12GMNN | |
| SCHEMBL1127704 | 0.84 | IDH1 (0.70) | GSK3BIDH1 | |
| SCHEMBL4689265 | 0.84 | GSK3B (0.50) | GSK3BGSK3AMEN1RGS12GMNN | |
| SCHEMBL4691089 | 0.84 | GSK3B (0.50) | GSK3BGSK3AMEN1RGS12GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |