Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.51 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5446149 | 1.00 | TNIK (0.74) | TNIKMEN1KMT2ANPC1RAB9A | |
| SCHEMBL5459994 | 1.00 | TNIK (0.74) | TNIKMEN1KMT2ANPC1RAB9A | |
| SCHEMBL5451267 | 0.89 | TNIK (0.59) | TNIKNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL5453345 | 0.89 | TNIK (0.59) | TNIKMEN1KMT2ANPC1RAB9A | |
| SCHEMBL5448399 | 0.89 | TNIK (0.62) | TNIKMEN1KMT2ANPC1RAB9A | |
| SCHEMBL5446191 | 0.86 | TNIK (0.59) | TNIKMEN1KMT2ANPC1RAB9A | |
| SCHEMBL5453529 | 0.86 | TNIK (0.59) | TNIKMAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL5451415 | 0.86 | TNIK (0.56) | TNIKMEN1KMT2ANPC1RAB9A | |
| SCHEMBL5459133 | 0.86 | TNIK (0.59) | TNIKMEN1KMT2AMAPTLMNA | |
| SCHEMBL5458879 | 0.85 | TNIK (0.58) | TNIKMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670804-A2 | HETEROBICYCLIC COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | GPC Biotech AG (DE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005023818-A2 | HETEROBICYCLIC COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | GPC BIOTECH AG (DE) | 2005-03-17 | — | — | WO | disclosed |