Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2746030 | 0.96 | KDR (0.82) | KDRCYP3A4CYP2D6SMN1; SMN2FLT1 | |
| SCHEMBL4548982 | 0.86 | KDR (1.00) | KDRCYP3A4CYP2D6FLT1FLT4 | |
| SCHEMBL4548985 | 0.85 | KDR (0.81) | KDRCYP3A4CYP2D6FLT1RET | |
| SCHEMBL2747174 | 0.85 | KDR (0.65) | KDRCYP3A4CYP2D6AURKALCK | |
| SCHEMBL4548984 | 0.83 | KDR (0.72) | KDRCYP3A4CYP2D6FLT1FLT4 | |
| SCHEMBL4548785 | 0.83 | KDR (0.84) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL4548910 | 0.82 | KDR (0.84) | KDRFLT1FLT4AURKALCK | |
| SCHEMBL4548903 | 0.82 | KDR (0.68) | KDRFLT1FLT4AURKALCK | |
| SCHEMBL4548986 | 0.82 | KDR (0.76) | KDRCYP3A4CYP2D6FLT1FLT4 | |
| SCHEMBL2747739 | 0.82 | KDR (0.84) | KDRFLT1FLT4AURKALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |