SCHEMBL5753387

SCHEMBL5753387

COc1ccc(CNC(=O)[C@H](CCC2CCCCC2)NC(=O)OC(C)(C)C)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1B Q00975 3/20 0.58
ALDH1A1 P00352 3/20 0.54
LMNA P02545 1/20 0.54
CPB2 Q96IY4 1/20 0.54
CTSS P25774 3/20 0.51
CTSL P07711 1/20 0.51
CTSK P43235 2/20 0.50
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
REN P00797 3/20 0.48
KMT2A Q03164 2/20 0.47
PPARG P37231 1/20 0.46
PPARA Q07869 1/20 0.46
MEN1 O00255 1/20 0.46
SRC P12931 1/20 0.45
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
MMP1 P03956 1/20 0.44
MMP2 P08253 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5349633 0.91 CACNA1B (0.62) CACNA1BALDH1A1LMNACPB2CTSS
SCHEMBL5349640 0.91 CACNA1B (0.62) CACNA1BALDH1A1LMNACPB2CTSS
SCHEMBL5356979 0.88 CACNA1B (0.59) CACNA1BALDH1A1LMNACPB2CTSS
SCHEMBL5354917 0.88 CACNA1B (0.71) CACNA1BALDH1A1LMNACPB2CTSS
SCHEMBL5350332 0.88 CACNA1B (0.71) CACNA1BALDH1A1LMNACPB2CTSS
SCHEMBL5361976 0.88 CACNA1B (0.57) CACNA1BALDH1A1LMNACPB2CTSS
SCHEMBL5348792 0.88 CACNA1B (0.57) CACNA1BALDH1A1LMNACPB2CTSS
SCHEMBL5342586 0.87 CACNA1B (0.70) CACNA1BALDH1A1LMNACPB2CTSS
SCHEMBL5364187 0.87 CACNA1B (0.53) CACNA1BALDH1A1LMNACPB2CTSS
SCHEMBL5350924 0.87 CACNA1B (0.53) CACNA1BALDH1A1LMNACPB2CTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0997147-B1 AMINO ACID DERIVATIVES ONO PHARMACEUTICAL CO (JP) 2006-03-15 EP claimed