Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5750903 | 0.91 | KDM4E (0.58) | KDM4EL3MBTL1POLBMAPTROCK2 | |
| SCHEMBL5751736 | 0.87 | KDM4E (0.56) | KDM4EL3MBTL1POLBMAPTROCK2 | |
| SCHEMBL6557824 | 0.86 | KDM4E (0.63) | KDM4EL3MBTL1POLBMAPTROCK2 | |
| SCHEMBL18674106 | 0.86 | KDM4E (0.67) | KDM4EL3MBTL1POLBMAPTROCK2 | |
| SCHEMBL6558299 | 0.82 | KDM4E (0.65) | KDM4EL3MBTL1POLBMAPTROCK2 | |
| SCHEMBL1438598 | 0.81 | KDM4E (0.73) | KDM4EL3MBTL1POLBMAPTROCK2 | |
| Hydrochloric Acid SCHEMBL5462828 | 0.80 | KDM4E (0.71) | KDM4EL3MBTL1POLBMAPTROCK2 | |
| Bromide SCHEMBL12078585 | 0.80 | KDM4E (0.71) | KDM4EL3MBTL1POLBMAPTROCK2 | |
| SCHEMBL1553020 | 0.79 | KDM4E (0.69) | KDM4EL3MBTL1POLBMAPTROCK2 | |
| SCHEMBL12228179 | 0.78 | KDM4E (0.73) | KDM4EL3MBTL1POLBMAPTROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1715862-A1 | KINASE INHIBITORS | Devgen NV (BE) | 2006-11-02 | — | — | EP | claimed |
| WO-2005082367-A1 | KINASE INHIBITORS | DEVGEN NV (BE) | 2005-09-09 | — | — | WO | claimed |